Antimicrobials
Rifampin

Rifampin

Spectrum of Activity

Dosing

General Information

  • Mycobacterial infections

  • Brucellosis

  • Osteomyelitis

  • Prosthetic joint infections due to Staphyloccocus aureus

Always use in combination with other agents

Lab

  • Basline and periodic LFTs

Clinical

  • Multiple drug interactions
  • Nausea/vomiting, diarrhea
  • Abnormal liver enzymes
  • Rash (Steven-Johnson syndrome)
  • Myopathy

Inducer of many CYP enzymes including 3A4, and 2C9.

Review patients medications carefully.

Should never be used as monotherapy.

May discolor bodily secretions (yellow-reddish). Caution in contact lens wearers.

Antimicrobial class: Antimycobacterial

Pregnancy category: C

Average serum half life: 3-4 hr

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Route of Elimination: Feces