Antimicrobials
Moxifloxacin

Moxifloxacin

High
Excellent (90 to 100%)

Dosing

General Information

Second line agent for pneumonia including CAP, HAP, aspiration.

Second line for some intra-abdominal infections.

Monitor QTc in patients with increased risk.

  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis
  • QTc prolongation - Increased risk with other agents that prolong QTc
  • Divalent cations including Ca, Mg - Decreased absorption
  • Warfarin - Increased INR
  • Rifampin - Decrease moxifloxacin levels

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic