Monitor QTc in patients with increased risk.
Prolongation of QTc interval. Association with increased cardiovascular mortality in observational studies.
Prolonged half life may contribute to macrolide resistance.
Very high tissue penetration and concentration intracellularly means in vivo activity may not be predicted by in vitro testing (e.g. Salmonella species).
Bioavailability: Has low oral bioavailability, measured at less than 40% but it rapidly distributes to tissues and therefore has low serum concentrations but high and persistent tissue concentrations.
Antimicrobial class: Macrolide
Pregnancy category: B
Average serum half life: 68 hours
Urine penetration: Poor
Lung penetration: Therapeutic
CSF penetration: Poor
Biliary penetration: Therapeutic