CAP Outpatient (Comorbidities Present)
Amoxicillin-Clavulanate

Amoxicillin-Clavulanate

Medium
Good (70 to 90%)

General Information

Oral:

  • Prophylaxis/treatment of bite wounds
  • Polymicrobial infections of the respiratory tract or abdomen
  • Skin and soft tissue infections

IV:

  • Community-acquired pneumonia (CURB65 score 3-5) – alternative to ceftriaxone
  • Acute exacerbations of chronic obstructive pulmonary disease or bronchiectasis
  • Aspiration pneumonia (community-acquired; poor oral hygiene/periodontal disease/putrid sputum)
  • Urinary tract infections (UTI) in patients who cannot take oral therapy
  • Human and animal bite infections – where IV to PO step-down therapy is indicated
  • Polymicrobial skin and soft tissue infections – where IV to PO step-down therapy indicated
  • Intra-abdominal infections – alternative to ceftriaxone +/- metronidazole
  • Head and neck infections

For prolonged therapy, monitor liver enzymes and function.

  • Allergy/rash (immediate or delayed)
  • Note EBV related rash
  • Cytopenias
  • Diarrhea
  • Hepatotoxicity due to clavulinate - usually mild, liver failure is rare.

Increased risk of rash with allopurinol.

Antimicrobial class: Aminopenicillin + Beta-lactamase inhibitor

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Therapeutic