- There is no evidence to support that IV therapy is superior to PO therapy in the management of uncomplicated cellulitis*.
- There is no evidence to support a minimum duration of IV therapy for the management of uncomplicated cellulitis*.
- Patients meeting the following suggested criteria can generally have their therapy converted from IV to PO:
- The patient is afebrile for at least 24 hours.
- Clinical improvement (such as: overall clinical improvement, decreased pain).
- There are no complicating factors (e.g. deeper tissue involvement, undrained abscess, insufficient perfusion to the affected area).
- The patient can tolerate oral medications that will achieve adequate tissue levels.
*Uncomplicated cellulitis: cellulitis WITHOUT periorbital involvement, severe sepsis, extensive bullous skin changes, undrained abscesses, deep tissue involvement, necrotizing fasciitis, or infected prosthetic material.