Surgical Prophylaxis

Surgical Prophylaxis


These guidelines provide general recommendations for appropriate prophylactic antibiotic use for common surgical procedures; the list of surgical procedures is not all inclusive

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  1. Bratzler, D., Dellinger, E. P., Olsen, K., Perl, T., Auwaerter, P., Bolon, M., et al. (2013). Clinical practice guidelines for antimicrobial prophylaxis in surgery. American Journal of Health System Pharmacy, 70, 195-28.
  2. Capital Health Halifax, Antimicrobial Handbook, Surgical Prophylaxis. Capital Health, 2012;(93-100).
  3. Blondel-Hill, Fryters. Surgical Prophylaxis in Adult Patients. Bugs and Drugs App. Accessed May 16, 2018.
  4. Lagace-Weins P, Rubinstein E. Adverse reactions to beta-lactam antimicrobials. Expert Opin Drug Saf 2012; 11:381-399.
  5. Van Eyk, N, van Schalkwyk J, et al. Antibiotic Prophylaxis in Gynaecologic Procedures. J Obstet Gynaecol Can 2012;34(4):382–391.
  6. Berrios-Torres SI, Umsheid CA, Bratzler DW, et al. Centers for Disease Control and Prevention Guidelines for the Prevention of Surgical Site Infection, 2017. JAMA Surg 2017;152(8):784-91.
  7. Sunnybrook Antimicrobial Handbook 2013, Surgical Antibiotic Prophylaxis. Sunnybrook Hospital, 2013;105-121.
  8. O’Neal PN, Itani KMF. Antimicrobial Formualtion and Delivery in the Prevention of Surgical Site Infection. Surgical Infections 2016;17(3):275-85.
  9. The Sanford Guide to Antimicrobial Therapy 2015, Table 15B – Antibiotic Prophylaxis to Prevent Surgical Infections in Adults.
  10. 2016 Sick Kids Drug Handbook and Formulary, Surgical Prophylaxis for Neonates and Paediatric Patients. The Hospital for Sick Children, 2016:360-76.
  11. Red Book: 2015 Report of the Committee on Infectious Diseases, Antimicrobial Prophylaxis in Pediatric Surgical Patients. American Academy of Pediatrics. Accessed online 2017/10/11.
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  13. Tita TN, Szychowski JM, Boggess K, et al. Adjunctive Azithromycin Prophylaxis for Cesarean Delivery. NEJM 375;13:1231-41
  14. Antibiotic Prophylaxis for Gynecological Proceddures. Clinical Management Guidelines for Obstetrician-Gynecologist. ACOG Practice Bulletin Nubmer 104, May 2009, Reaffirmed 2014.
  15. Eyk NV and Schalkwyk JV. Antibiotic Prophylaxis in Gynaecologic Procedures. J Obstet Gynaecol Can 2012;34(4):382-391
  16. Wolf JS, Bennett CJ, Dmochowski RR, et al. Urological Surgery Antimicrobial Prophylaxis – Best Practice Statement from the American Urological Association. Published 2008, Reviewed and Validity Confirmed 2011; amended 2012. (Accessed online January 4, 2018)
  17. Blumenthal KG, Ryan EE, Li Y, et al. The Impact of a Reported Penicillin Allergy on Surgical Site Infection Risk. Clinical Infectious Diseases 2018;66(3):329-336
  18. Hoff WS, Bonadies JA, Cachecho R and Dorlac WC. East Practice Management Guidelines Work Group: Update to Practice Management Guidelines for Prophylactic Antibiotic Use in Open Fractures. J Trauma. 2011 Mar;70(3):751-4.
  19. Schmitt SK. Treatment and Prevention of Osteomyelitis Following Trauma in Adults. In: UpToDate, Sexton DJ (Ed), UpToDate, Waltham, MA. (Accessed on May 16, 2018)
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