The use of antibiotics in acute exacerbations of chronic obstructive pulmonary disease (AECOPD) is controversial
Antimicrobial therapy is only recommended when AECOPD is accompanied by an acute change in all 3 cardinal symptoms or at least 2 of the 3 cardinal symptoms, if increased sputum purulence is one of the 2 symptoms.
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Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease (2018 Report)
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