Based on patient evaluation, consider obtaining cultures before start of antimicrobial therapy and/or repeat if not improving after 72 hours of antimicrobial therapy
If a patient has received an antibiotic in the last 3 months the therapy chosen should be a regimen based on a different mechanism of action regardless of the clinical success
Tailor antibiotic therapy for sputum culture results if available
Dose adjustment required in renal impairment for all antimicrobials outlined below except doxycycline
5 days