Voriconazole
Adult

Adult

Note

Therapeutic drug monitoring should be considered

IV

6 mg/kg IV q12h x 2 doses, then 4 mg/kg IV q12h thereafter

PO

Patients weighing ≥40kg

400mg PO q12h x 2 doses, then 200mg PO q12h

Patients weighing <40kg

200mg PO q12h x 2 doses, then 100mg PO q12h

Invasive aspergillosis (IDSA recommendations)
  • May consider oral therapy in place of IV with dosing of 4 mg/kg PO rounded up to convenient tablet dosage form every 12 hours
  • IV administration preferred in serious infections as comparative efficacy with the oral route has not been established