ValACYclovir
Renal

Renal

Not On Dialysis

Herpes zoster (shingles)
  • CrCl 30-49: 1g PO q12h
  • CrCl 10-29: 1g PO q24h
  • CrCl <10: 500mg PO q24h
Herpes labialis
  • CrCl 30-49: 1g PO q12h x 2 doses
  • CrCl 10-29: 500mg PO q12h x 2 doses
  • CrCl <10: 500mg PO as a single dose
Primary genital herpes
  • CrCl 30-49: 1g PO q12h
  • CrCl 10-29: 1g PO q24h
  • CrCl <10: 500mg PO q24h
Recurrent genital herpes
  • CrCl 30-49: 500mg PO q12h x 3 days OR 1g pO q24h x 5 days
  • CrCl <30: 500mg PO q24h
Herpes simplex/Varicella zoster treatment in oncology patients
  • CrCl 30-49: 1g PO q12h
  • CrCl 10-29: 1g PO q24h
  • CrCl <10: 500mg PO q24h
Herpes simplex/Varicella zoster prophylaxis in oncology patients
  • CrCl 30-49: 500mg PO q8-12h
  • CrCl 10-29: 500mg PO q12h
  • CrCl <10: 500mg PO q24h

Intermittent Hemodialysis (IHD)

Herpes zoster (shingles)

1g PO 3x weekly after dialysis, if receiving dialysis three times weekly

Herpes labialis

500mg PO as a single dose Administer dose after a dialysis session

Primary genital herpes

500mg PO q24h Administer dose after dialysis on dialysis days

Recurrent genital herpes

500mg PO q24h Administer dose after dialysis on dialysis days

Herpes simplex/Varicella zoster treatment in oncology patients

1g PO three times weekly after dialysis, if receiving dialysis three times weekly

Herpes simplex/Varicella zoster prophylaxis in oncology patients

500mg PO q24h Administer dose after dialysis on dialysis days