Antimicrobials
Trimethoprim

Trimethoprim

Low
Moderate

Spectrum of Activity

Dosing

General Information

  • Urinary Tract Infections
  • Can be used in sulfonamide-allergic or sulfonamide-intolerant patients
  • Renal injury and hyperkalemia, particularly in older patients (65 or older)
  • Regular monitoring of kidney function and electrolytes if prolonged use, over age 65, use of ACEi, ARB, or K-sparing diuretic, baseline renal injury, or other risks for AKI/hyperkalemia
  • Renal injury and hyperkalemia, particularly in older patients (65 or older)
  • Sudden cardiac death - Higher risk in patients on angiotensin converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB), K sparing diuretic (e.g. spironolactone)
  • Aseptic meningitis is rare