Monitor creatinine at baseline and every 2 to 3 days.
Monitor for vestibulotoxicity/ototoxicity, discontinue if any signs.
Once daily dosing: Target trough within 30 minutes before dose <1 mg/mL
Multiple daily dosing: Peak monitoring poorly supported by literature, but target peak 6-10 mg/mL for most infections; trough < 2 mg/mL only if using >4 days
NB: Trough level is 0-30min before a dose (usually pre-3rd or 4th), and peak is 30-60min after dose infused (usually post-3rd or 4th).
In critically ill patients, check peak level after the 1st dose as volume of distribution and renal function may change rapidly.