Antimicrobials
Tigecycline

Tigecycline

Restricted

Medium
N/A

Spectrum of Activity

Dosing

General Information

Reserved for highly resistant infections or when significant allergies restrict other options and when there is documented susceptibility.

Associated with more treatment failures than alternatives and excess mortality - Only use when alternatives are not suitable

Note: Pseudomonas and Proteus vulgaris are inherently resistant

  • Avoid or use with caution in patients with tetracycline reactions.

  • GI side effects very prominent with significant nausea and vomiting.

  • Tetracycline related adverse events: photosensitivity, acute pancreatitis.

  • Increased liver enzymes

  • Rash

  • Oral contraceptives
  • increases INR with warfarin

Documented safety concerns in bacteremia, only use if no other options

Antimicrobial class: Tetracycline derivative

Pregnancy category: D

Average serum half life: 42 hours

Lung penetration: Therapeutic

Biliary penetration: Therapeutic