Posaconazole
Adult

Adult

IV

Loading dose 300mg IV infusion q12h on day 1

Followed by 300mg IV infusion q24h starting on day 2

PO

Note
  • Delayed release tablet and oral suspension are NOT bioequivalent; favour the delayed release tablet
  • No adjustment needed for renal impairment
Delayed-Release Tablet

Loading dose of 300mg PO q12h on day 1

Followed by 300mg PO q24h starting on day 2

Oral Suspension
  • Prophylaxis: 200mg PO three times daily
  • Treatment of invasive fungal infections: 400mg PO q12h OR 200mg four times daily for patients unable to tolerate a meal or nutritional supplement