Antimicrobials
Nitrofurantoin

Nitrofurantoin

Low
Excellent

Dosing

General Information

First line treatment for uncomplicated urinary tract infections (cystitis in females) with normal renal function

Note:

  • Do NOT use for pyelonephritis or other systemic infections
  • Interstitial pneumonitis and fibrosis especially with prolonged use
  • Peripheral neuropathy

Antacids decrease absorption

  • Think of this drug as a urinary antiseptic.
  • Should NOT be used for complicated urinary infections or urosepsis
  • Not recommended in males due to inadequate tissue penetration, especially with possible occult prostatitis
  • Causes urine discoloration

Antimicrobial class: Nitrofuran

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: None

CSF penetration: None

Biliary penetration: None