Antimicrobials
Moxifloxacin

Moxifloxacin

High
Excellent

Spectrum of Activity

Dosing

General Information

Community acquired pneumonia requiring ICU admission - NOT a first-line agent, see guidelines

Monitor QTc in patients with increased risk

  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis

QTc prolongation - Increased risk with other agents that prolong QTc

Divalent cations (including Ca, Mg) - Decreased absorption

Warfarin - Increased INR

Rifampin - Decrease moxifloxacin levels

  • Avoid dairy products, antacids, and other sources of divalent cations (Ca, Fe, Mg, Al, Zn) which can chelate moxifloxacin and prevent absorption
  • Must hold continuous tube feeding 2 h before and 2 h after administration.

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 12 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic