Antimicrobials
Micafungin

Micafungin

Low
N/A

Spectrum of Activity

Dosing

General Information

Primary Indication(s)

  • Empiric antifungal for severely ill patients with invasive Candida infection or patients at risk of fluconazole resistance (e.g. receiving fluconazole prophylaxis)
  • Empiric yeast therapy for febrile neutropenia
  • Fungal endocarditis

Alternative

  • An option for invasive Aspergillosis infections, but amphotericin or voriconazole is usually preferred
  • Periodic Liver enzymes, renal function, CBC with differential
  • Elevations in hepatic enzymes
  • Phlebitis
  • Headache
  • GI upset, diarrhea
  • Fever

Increases levels of sirolimus

Antimicrobial class: Echinocandin

Pregnancy category: C

Average serum half life: 15 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic