Antimicrobials
MetroNIDAZOLE

MetroNIDAZOLE

Low
Excellent

Spectrum of Activity

Dosing

General Information

Suspected or confirmed anaerobic infections including: - Intra-abdominal - Biliary - Central nervous system - C. difficileGiardia - Pelvic infections

Also used in: - Bacterial vaginosis - Hepatic encephalopathy

Assess for peripheral/optic neuropathy with prolonged therapy (>6wks) or if symptoms develop.

GI symptoms common - Especially nausea/vomiting and metallic taste

Peripheral/optic neuropathy with extended therapy

Disulfiram-like reaction (severe vomiting)

Rare neurotoxicity including aseptic meningitis and encephalopathy

Ethanol - Disulfiram-like reaction

Increases levels of:

  • Cyclosporine - Lithium - Warfarin - Phenobarbital - Phenytoin

Bacterial, protozoal and ameobic DNA is fragmented by reactive nitroso-imidazole radicals.

Antimicrobial class: Nitroimidazole

Pregnancy category: B

Average serum half life: 10 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Therapeutic