Antimicrobials
Linezolid

Linezolid

Restricted

Low
Excellent

Dosing

General Information

  • Vancomycin-resistant Enterococcus (VRE) infections when daptomycin cannot be used
  • MRSA infections in which vancomycin or daptomycin cannot be used
  • Inhibits monoamine oxidase. Risk of serotonin syndrome if given to patients taking SSRIs, serotonin norepinephrine reuptake inhibitors or MAOI – check for drug interactions
  • Predictable cytopenia after 2 weeks of therapy: monitor CBC at least once a week
  • Lactic acidosis, peripheral neuropathy, optic neuropathy after 4 weeks of therapy
  • Visual testing for therapy >3 months or if symptoms develop on therapy.
  • Serotonin syndrome
  • Rash
  • Elevated liver enzymes
  • Lactic acidosis
  • Myelosuppression (usually with >2weeks therapy)- reversible
  • Peripheral/optic neuropathy with prolonged courses

SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.

Rifampin decreases linezolid levels.

Excellent oral bioavailability (100%)

Antimicrobial class: Oxazolidinone

Pregnancy category: C

Average serum half life: 5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic