General Information

Lower respiratory infection (CAP requiring ICU admission, HAP) - NOT a first-line agent, see guidelines

Monitor QTc in patients with increased risk.

  • QTc prolongation
  • Dysglycemia
  • Rash
  • Tendinopathy and rupture
  • GI upset
  • Weakness exacerbation in myasthenia gravis
  • CNS toxicity including confusion, psychosis
  • Other QTc prolonging agents
  • Divalent cations (e.g. Ca, Mg, etc.) - Decreased absorption
  • Warfarin - Increased INR
  • Avoid dairy products, antacids, and other sources of divalent cations (Ca, Fe, Mg, Al, Zn) which can chelate levofloxacin and prevent absorption
  • Must hold continuous tube feeding 2 h before and 2 h after administration.
  • While levoFLOXacin has some activity against Pseudomonas, ciprofloxacin should be preferred for definitive therapy

Antimicrobial class: Fluoroquinolone

Pregnancy category: C

Average serum half life: 7 hours

Biliary penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic