Antimicrobials
Imipenem+Cilastatin

Imipenem+Cilastatin

Restricted

High
N/A

Dosing

General Information

Severe hospital acquired infections or patients with risk factors for multi-drug resistance where broad spectrum coverage is required

Seizure risk

  • Immediate or delayed hypersensitivity reactions
  • C. difficile
  • Neurotoxicity

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Meropenem preferred for CNS infections and when CrCl < 30 mL/min

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Use meropenem

Biliary penetration: Therapeutic