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Severe hospital acquired infections or patients with risk factors for multi-drug resistance where broad spectrum coverage is required
Seizure risk
Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold
Meropenem preferred for CNS infections and when CrCl < 30 mL/min
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 1 hour
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Use meropenem
Biliary penetration: Therapeutic
Antimicrobials
