Spectrum of Activity


General Information

CMV treatment and prophylaxis/maintenance

Monitor CBC for cytopenias and creatinine

  • Cytopenias (usually responds to G-CSF)
  • Hyperhidrosis
  • GI upset
  • Diarrhea
  • Increased creatinine

Mycophenolate can increase ganciclovir concentration

  • Valganciclovir is the prodrug of ganciclovir
  • Resistance can occur; if suspected, consult ID

Antimicrobial class: Antiviral. Nucleoside analogue.

Pregnancy category: C (US Black Box warning: Based on animal data and limited human data, ganciclovir has the potential to cause birth defects and may cause temporary or permanent inhibition of spermatogenesis in males and suppression of fertility in females.)

Average serum half life: 3.5 hours

CSF penetration: Therapeutic