Antimicrobials
Fluconazole

Fluconazole

Low
Excellent

Spectrum of Activity

Dosing

General Information

Candida infections both mucocutaneous and invasive - i.e. Candidemia.

Cryptococcus and Coccidioides infections.

Antifungal prophylaxis in immunocompromised patients.

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement. Consider liver enzyme monitoring.

  • Drug interactions
  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • Alopecia
  • GI upset

Many via CYP450. Suggest review specific patient medications, perform interaction screen.

Fluconazole increases levels of phenytoin, cyclosporine, tacrolimus, warfarin, oral hypoglycemics.

Risk when combining with other QTc prolonging medications.

Antimicrobial class: Triazole antifungal

Pregnancy category: C

Average serum half life: 20 hours

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic