Antimicrobials
Erythromycin

Erythromycin

Low
Moderate

Dosing

General Information

  • For most indications, azithromycin or clarithromycin are preferred
  • Motility agent
  • As part of a combination therapy for bowel preparation for colorectal surgery
  • Monitor QTc in patients with increased risk
  • Potential for drug interactions
  • Nausea/vomiting (25%)
  • Diarrhea (8%)
  • Prolonged QT interval and Torsades de Pointes
  • Substrate of CYP3A4. Multiple CYP450 interactions possible
  • Caution with QTc prolonging medications
  • May increase digoxin and carbemazepine levels
  • Statins: risk rhabdomyolysis

Formulary Product: Erythromycin 250mg capsules containing EC pellets

Antimicrobial Class: Macrolide

Route of Elimination: Primarily hepatic