Antimicrobials
Ertapenem - Non-formulary

Ertapenem - Non-formulary

Restricted

High
N/A

Spectrum of Activity

Dosing

General Information

Treatment of resistant Gram-negative infections when broad spectrum coverage is needed but not requiring anti-Pseudomonas or enterococcal activity

Treatment of polymicrobial diabetic foot infections when suspected bacteria have a high likelihood of resistance to cefazolin or ceftriaxone

Note:

  • Unlike other carbapenems, does not cover Pseudomonas.
  • No activity against enterococci or Stenotrophomonas
  • Immediate and delayed-type allergy
  • GI disturbance
  • Cytopenias, eosinophilia, positive Coombs
  • Liver enzyme abnormalities
  • Seizure risk lower than other carbapenems

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 4 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

Biliary penetration: Moderate