Antimicrobials
Clindamycin

Clindamycin

High
Excellent

Dosing

General Information

Primary

  • For use in combination for treatment of Group A streptococcus (Streptococcus pyogenes) or Staphylococcus aureus infections causing toxic shock syndrome or necrotizing fasciitis

Alternative

  • Non-invasive MRSA infections, if susceptible, without alternative option such as TMP/SMX or doxycycline
  • Part of combination therapy for Pneumocystis, Toxoplasma

Note

  • Increasing resistance of Bacteroides, metronidazole is the drug of choice in such infections

Monitor for diarrhea

  • C. difficile colitis
  • Cytopenia
  • Abnormal liver enzymes

Antimicrobial class: Lincosamide

Pregnancy category: B

Average serum half life: 2.4 hours

Urine penetration: Poor

Lung penetration: Therapeutic

CSF penetration: Poor

Biliary penetration: Therapeutic