Antimicrobials
Cefotaxime

Cefotaxime

High
N/A

Dosing

General Information

  • May be used in place of ceftriaxone for patients with biliary sludging or cholestatic hepatitis.
  • EMPIRIC therapy of severely ill patients with suspected Gram-negative infection
  • Documented Gram-negative infection resistant to 1st and 2nd generation cephalosporins
  • Meningitis
  • Spontaneous bacterial peritonitis, community-acquired secondary peritonitis (or hospital acquired with no previous antimicrobial therapy), or intra-abdominal abscess.
  • Community acquired pneumonia

Does NOT cover Pseudomonas and other resistant Gram-negative, ESBLs or AmpC producing Enterobacteriaceae

- Allergy (immediate or delayed) - Positive Coombs test - Neutropenia - Abnormalities in liver enzymes - Diarrhea

  • C. difficile diarrhea

Prefer ceftriaxone for CNS infection in renal failure.

Antimicrobial class: 3rd Generation Cephalosporin

Pregnancy category: B

Average serum half life: 1.5 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate