Cefepime
Renal

Renal

Dosing Information

  • Usual dosing for uncomplicated mild to moderate infections: 1-2 g IV q8h - q12h
  • Usual dosing for severe infections including febrile neutropenia, hospital acquired pneumonia, deep space infections or coverage for Pseudomonas aeruginosa:  2 g IV q8h

If usual dose is 1-2 g IV q8h - q12h

CrCl 30 - 59 mL/min

1-2 g IV q12h - q24h

CrCl 10 - 29 mL/min

1-2 g IV q24h

CrCl <10 mL/min

1 g IV q24h

Intermittent Hemodialysis
  • 1g IV q24h
    • Administer dose after dialysis on dialysis days

OR

  • 2g IV after dialysis three times weekly (if receiving dialysis three times weekly)

If usual dose is 2 g IV q8h

CrCl 30 - 59 mL/min

2 g q12h

CrCl 10 - 29 mL/min

2 g q24h

CrCl <10 mL/min

1 g q24h

Intermittent Hemodialysis
  • 1g IV q24h
    • Administer dose after dialysis on dialysis days

OR

  • 2g IV after dialysis three times weekly (if receiving dialysis three times weekly)