Antimicrobials
Cefepime

Cefepime

Restricted

High
N/A

Spectrum of Activity

Dosing

General Information

Febrile neutropenia in pediatrics:

  1. With true penicillin allergy; or
  2. Receiving high-dose methotrexate

Need to add metronidazole if worry of anaerobic infection

  • Allergy (immediate & delayed) - Positive Coombs - Thrombocytopenia, neutropenia - Non-convulsive status epilepticus
  • Transient liver function test increase
  • Diarrhea

Antimicrobial class: 4th generation Cephalosporin

Pregnancy category: B

Average serum half life: 2 hours

Biliary penetration: Moderate

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic