Ampicillin
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis (EGFR)

0 - 10 eGFR

2g IV q12-24h

10 - 50 eGFR

2g IV q6-12h

50+ eGFR

2g IV q6h

Intermittent Dialysis

1-2g IV q12-24h, dose after HD on dialysis days

Continuous Dialysis

Load 2g then 1-2g IV q6h