1-2g IV q4-6h
2g IV q4h for meningitis or endocarditis
0 - 10 eGFR10 - 50 eGFR50+ eGFR2g IV q12-24h2g IV q6-12h2g IV q6h
1-2g IV q12-24h, dose after HD on dialysis days
Load 2g then 1-2g IV q6h
Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria
Allergy and rash as for all beta-lactams
EBV related rash (not allergy)
Rare: cytopenias, +ve Coombs
Increased risk of rash with allopurinol
Antimicrobial class: aminopenicillin
Pregnancy category: B
Average serum half life: 1.0
Biliary penetration: Therapeutic
CSF penetration: Therapeutic
Lung penetration: Therapeutic
Urine penetration: Therapeutic