Antimicrobials
Ampicillin

Ampicillin

C difficile risk
Low
Oral Bioavailability
N/A
Cost
$35/day

Dosing

1-2g IV q4-6h

2g IV q4h for meningitis or endocarditis

0 - 10 eGFR10 - 50 eGFR50+ eGFR2g IV q12-24h2g IV q6-12h2g IV q6h

1-2g IV q12-24h, dose after HD on dialysis days

Load 2g then 1-2g IV q6h

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria

Allergy and rash as for all beta-lactams

EBV related rash (not allergy)

Rare: cytopenias, +ve Coombs

Increased risk of rash with allopurinol

Antimicrobial class: aminopenicillin

Pregnancy category: B

Average serum half life: 1.0

Biliary penetration: Therapeutic

CSF penetration: Therapeutic

Lung penetration: Therapeutic

Urine penetration: Therapeutic