Meropenem
Renal

Renal

In the setting of rapidly improving/worsening renal function, calculations of eGFR are inaccurate, and dosing should be based on estimated renal function instead.

If worsening renal function, actual GFR is likely lower than calculated.

If improving renal function, actual GFR is likely higher than calculated eGFR.

Not On Dialysis: Standard Dose

eGFR 0 - 10

500mg IV q24h

eGFR 10 - 25

1g IV q12h

eGFR 25 - 50

1g IV q12h

eGFR > 50

1g IV q8h

Not On Dialysis: Meningitis Dose

eGFR 0 - 10

1g IV 24h

eGFR 10 - 25

2g IV q12h

eGFR 25 - 50

2g IV q12h

eGFR > 50

2g IV q8h

Intermittent Dialysis

500mg IV q24h

Dose after HD on dialysis days

Continuous Dialysis

1g IV q8h

Depends on flow rate