Antimicrobials
Meropenem

Meropenem

C difficile risk
Medium
Oral Bioavailability
N/A

Dosing

Standard Dose 500mg IV q6h or 1g IV q8h

Meningitis 2g IV q8h

eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 50 500mg IV q24h1g IV q12h1g IV q12h1g IV q8h

eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 501g IV 24h2g IV q12h2g IV q12h2g IV q8h

500mg IV q24h

Dose after HD on dialysis days

1g IV q8h

Depends on flow rate

General Information

Therapy of serious, often nosocomial infections involving resistant gram negative organisms

  •  Immediate and delayed-type allergy

  •  GI disturbance

  •  Cytopenias, positive Coombs

  •  Liver enzyme abnormalities

Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold

Antimicrobial class: Carbapenem

Pregnancy category: B

Average serum half life: 1 hour

Biliary penetration: Therapeutic

CSF penetration: Moderate

Lung penetration: Therapeutic

Urine penetration: Therapeutic