eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 50 500mg IV q24h1g IV q12h1g IV q12h1g IV q8h
eGFR 0 - 10 eGFR 10 - 25 eGFR 25 - 50 eGFR > 501g IV 24h2g IV q12h2g IV q12h2g IV q8h
500mg IV q24h
Dose after HD on dialysis days
1g IV q8h
Depends on flow rate
Therapy of serious, often nosocomial infections involving resistant gram negative organisms
Immediate and delayed-type allergy
GI disturbance
Cytopenias, positive Coombs
Liver enzyme abnormalities
Valproic acid - Carbapenems decrease valproate levels and may decrease seizure threshold
Antimicrobial class: Carbapenem
Pregnancy category: B
Average serum half life: 1 hour
Biliary penetration: Therapeutic
CSF penetration: Moderate
Lung penetration: Therapeutic
Urine penetration: Therapeutic
