600mg PO/IV q12h
Targeted or empiric therapy for gram positive infections including skin and soft tissue, and pneumonia.
Covers MRSA and VRE.
CBC at least once/week
Visual testing for therapy >3 months or if symptoms develop on therapy.
Elevated liver enzymes
Myelosuppression (usually with >2weeks therapy) - reversible
Peripheral/optic neuropathy with prolonged courses
SSRI and other serotonergics/MAOIs - Increased risk of serotonin syndrome.
Rifampin decreases linezolid levels.
Antimicrobial class: Oxazolidinone
Pregnancy category: C
Average serum half life: 5 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Therapeutic