Caesarean Delivery
Vancomycin IV

Vancomycin IV

None
N/A

Dosing

General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.

Collect trough 0-1h before 3rd or 4 th dose if abnormal/fluctuating renal function.

Target trough 15-20 mcg/mL for most serious infections, 20-25mcg/mL for meningitis

If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval.

If trough >20, increase dosing interval or decrease dose

  • Nephrotoxicity
  • Cytopenias
  • Rash including Stevens-Johnson Syndrome
  • Red man syndrome (histamine release- slow down infusion)

Aminoglycosides may potentiate nephrotoxicity.

May enhance neuromuscular blockade of NM blocking agents.

Careful with concomitant nephrotoxins.

Antimicrobial class: Glycopeptide

Pregnancy category: C

Average serum half life: 8 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Moderate

Biliary penetration: Moderate