Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections.
Collect trough 0-1h before 3rd or 4 th dose if abnormal/fluctuating renal function.
Target trough 15-20 mcg/mL for most serious infections, 20-25mcg/mL for meningitis
If trough low, increase dose (do not exceed 2g/dose) OR decrease dosing interval.
If trough >20, increase dosing interval or decrease dose
Aminoglycosides may potentiate nephrotoxicity.
May enhance neuromuscular blockade of NM blocking agents.
Careful with concomitant nephrotoxins.
Antimicrobial class: Glycopeptide
Pregnancy category: C
Average serum half life: 8 hours
Urine penetration: Therapeutic
Lung penetration: Therapeutic
CSF penetration: Moderate
Biliary penetration: Moderate
Antimicrobials
