Antimicrobials
Daptomycin

Daptomycin

Restricted

Low
N/A

Spectrum of Activity

Dosing

General Information

Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection

Creatine kinase weekly

  • GI side effects common
  • Rash
  • Phlebitis
  • Increased INR
  • Myopathy including rhabdomyolysis

Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.

Higher doses used for endovascular infection.

Requires an Infectious Disease Consult for use. ASP can authorize empiric use until ID available for consult

Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.

Antimicrobial class: Cyclic Lipopeptide

Pregnancy category: B

Average serum half-life: 9 hours

Urine penetration: Therapeutic

Lung penetration: Poor

CSF penetration: Poor