Restricted
Targeted therapy of resistant gram positive infections with MRSA (particularly when MIC≥2) and VRE including endovascular infection
Creatine kinase weekly
Statins and fibrates - Increased myopathy. Monitor creatine kinase or hold while on daptomycin therapy.
Higher doses used for endovascular infection.
Requires an Infectious Disease Consult for use. ASP can authorize empiric use until ID available for consult
Inactivated by pulmonary surfactant and therefore insufficient for pulmonary infection.
Antimicrobial class: Cyclic Lipopeptide
Pregnancy category: B
Average serum half-life: 9 hours
Urine penetration: Therapeutic
Lung penetration: Poor
CSF penetration: Poor