Antimicrobials
Caspofungin

Caspofungin

Low
N/A

Dosing

General Information

Caspofungin is often used in management of suspected and confirmed invasive fungal infections, particularly Candidiasis and Aspergillosis

Liver enzymes at baseline and every 1-2 weeks

  • Infusion-related reactions (rash, pruritis)
  • Phlebitis
  • Headache
  • Nausea and vomiting
  • Elevations in hepatic enzymes
  • Decreases levels of Tacrolimus
  • Cyclosporine may increase levels of Caspofungin
  • Rifampin may decrease Caspofungin concentrations

Caspofungin has poor vitreous, CNS and urinary penetration. It should not be used for treatment of Candida urinary tract infections

All patients with candidemia should have an ID consult. An automatic referral will occur as per ASP protocol

Antimicrobial class: Echinocandin

Biliary penetration: Therapeutic

CSF penetration: Poor

Lung penetration: Therapeutic

Urine penetration: Poor