Vancomycin IV

Vancomycin IV



General Information

Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections

Red man syndrome (histamine release - slow down infusion), nephrotoxicity, cytopenias.

Management: Slow infusion to infuse over 120 minutes. Pre-dose with Diphenhydramine IV 0.5mg/kg/DOSE.

Aminoglycosides may potentiate nephrotoxicity.

Use caution and increase monitoring of renal function when used with concomitant nephrotoxins.

Antimicrobial class: Glycopeptide

Average serum half life:

  • Newborns: 6 to 10 hours
  • Infants and Children 3 months to 4 years: 4 hours
  • Children and Adolescents >3 years: 2.2 to 3 hours

Route of Elimination: Primarily via glomerular filtration; excreted as unchanged drug in the urine (80% to 90%)