General Spectrum of Activity
Suspected or proven MRSA, coagulase-negative Staphylococcal infections, Enterococcal infections
Red man syndrome (histamine release - slow down infusion), nephrotoxicity, cytopenias.
Management: Slow infusion to infuse over 120 minutes. Pre-dose with Diphenhydramine IV 0.5mg/kg/DOSE.
Aminoglycosides may potentiate nephrotoxicity.
Use caution and increase monitoring of renal function when used with concomitant nephrotoxins.
Antimicrobial class: Glycopeptide
Average serum half life:
Route of Elimination: Primarily via glomerular filtration; excreted as unchanged drug in the urine (80% to 90%)