Antimicrobials
Vancomycin (PO)

Vancomycin (PO)

None
None

Spectrum of Activity

General Information

Only indication is in the therapy of C. difficile infection, particularly recurrent or severe disease

Possibility of accumulation in severe renal dysfunction; consider checking a vancomycin level in dialysis patients

Nausea, vomiting, diarrhea

Avoid concurrent administration of oral vancomycin and bile acid sequestrants (may dimish therapeutic effect of vancomycin).

No oral absorption.

May increase vancomycin resistant enterococci colonization in the gut

Cost listed above reflects oral liquid. Capsules are almost 10X more costly

Antimicrobial class: glycopeptide

Average serum half life: serum half life not available due to low systemic absorption

Route of Elimination: Primarily feces as limited absorption