Penicillin VK (oral)

C difficile risk
Low
Oral Bioavailability
Excellent

Dosing

Infants and Children <12 years: 25-75 mg/kg/DAY PO divided q6-8h. Max 2000 mg/DAY.Children >12 years and Adolescents: 375-2000 mg/DAY PO divided q6-8h or dose based on weight: 25- 75 mg/kg/DAY PO divided q6-8h.Prophylaxis for asplenia (Infants and children <3 years), PO: 250 mg/DAY divided into 2 daily dosesProphylaxis for asplenia (children ≥3 years), PO: 500 mg/DAY divided into 2 daily doses.

No dose adjustment recommended.

Use with caution; excretion is prolonged in patients with renal impairment. Consult with a pharmacist for dosing in renal impairment.

General Information

  • Streptococcal infections and therapy of documented susceptible infection not requiring parenteral therapy (i.e. upper respiratory tract)

  • Prophylaxis after rheumatic fever

  • Monitor for allergy.

  • Periodic CBC, SCr

  • Allergy (anaphylaxis) and other rash

  • Cytopenias, Positive Coombs, Eosinophilia

  • Serum sickness

  • Acute interstitial nephritis

Antimicrobial class: Penicillin

Average serum half life: No pediatric data. Adults: 30 minutes; prolonged in patients with renal impairment

Route of Elimination: Penicillin V and its metabolites are excreted in urine

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