Antimicrobials
Nitrofurantoin

Nitrofurantoin

Low
N/A

General Information

Uncomplicated cystitis in patients with normal renal function

Interstitial pneumonitis and fibrosis esp. with prolonged use

Peripheral neuropathy

Does not provide adequate renal concentrations for treatment of systemic infections (i.e urosepsis, pyelonephritis); appropriate for cystitis and/or urinary prophylaxis.

Antimicrobial class: Nitrofuran

Average serum half life: No pediatric data. Adults: 20 to 60 minutes and is prolonged with renal impairment

Route of Elimination: As metabolites and unchanged drug (40%) in the urine and small amounts in the bile; renal excretion is via glomerular filtration and tubular secretion