General Information

Lower respiratory infection (CAP, HAP), intraabdominal infection

Monitor QTc in patients with increased risk

Dizziness, insomnia, rash, n/v, abdominal pain.

Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.

Increased risk when combined with other QTc prolonging agents.

AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.

Increased risk of tendon rupture with concomitant use of corticosteroids.

Monitor INR with warfarin.

Antimicrobial class: Fluoroquinolone

Average serum half life:

  • Infants ≥6 months to 5 years: ~4 hours.
  • Children 5-16 years: 4.8-6 hours.
  • Adults: 6-8 hours

Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces