Lower respiratory infection (CAP, HAP), intraabdominal infection
Monitor QTc in patients with increased risk
Dizziness, insomnia, rash, n/v, abdominal pain.
Tendinopathy and rupture, retinal detachment, peripheral neuropathy & QTc prolongation have been reported.
Increased risk when combined with other QTc prolonging agents.
AVOID concomitant administration with antacids, multivitamin & mineral supplements. Space doses by 2 hours.
Increased risk of tendon rupture with concomitant use of corticosteroids.
Monitor INR with warfarin.
Antimicrobial class: Fluoroquinolone
Average serum half life:
Route of Elimination: 87% excreted unchanged in urine over 48 hours by tubular secretion and glomerular filtration; 4% in feces