Antimicrobials
Fluconazole

Fluconazole

Low
N/A

Spectrum of Activity

General Information

  • Candida infections both mucocutaneous and invasive - i.e. Candidemia
  • Cryptococcus and Coccidioides infections
  • Antifungal prophylaxis in immunocompromised

Consider QTc monitoring if concomitant drugs affecting the interval or elevated baseline measurement

  • QTc prolongation
  • Hepatic enzyme abnormalities
  • Rash
  • GI upset

Many via CYP450 - suggest review interactions with pharmacist.

Risk when combining with other QTc prolonging medications

Antimicrobial class: Triazole antifungal

Average serum half life:

  • Premature neonates: 47-73.6 hours.
  • Pediatrics (9 months to 15 years): oral 19.5-25 hours
  • 5- 15 years: IV 15-18 hours
  • Adults: Normal renal function: ~30 hours

Route of Elimination: 80% unchanged in urine; 11% metabolites in urine.