Spectrum Of Activity
Anaerobic infections above the diaphragm, especially dental infection.
Gram positive skin and soft tissue infections including necrotizing fasciitis as an adjunctive agent to a beta lactam for reducing toxin production.
Skin & soft tissue infections involving susceptible MRSA.
Susceptible infections and surgical prophylaxis in setting of IgE mediated beta-lactam allergy.
For decreasing toxin production in toxic shock syndrome.
Monitor for diarrhea, CBC, hepatic & renal function.
If severe diarrhea, consider C.diff infection.
Allergy (immediate & delayed), GI upset, diarrhea, cytopenia, abnormal liver enzymes, pseudomembranous colitis.
Some preparations of Clindamycin injection contain benzyl alcohol, which has caused gasping syndrome in neonates.
Antimicrobial class: Lincosamide
Average serum half life:
Premature neonates: 8.7 hours
Full term neonates: 3.6 hours.
Infants 1 month to 1 year: 3 hours.
Children and Adults: 2-3 hours
Route of Elimination: Mostly hepatic metabolism. 10% of an oral dose excreted in urine and 3.6% excreted in feces as active drug and metabolites.