Antimicrobials
Clarithromycin

Clarithromycin

Medium
Excellent

Spectrum of Activity

General Information

CAP, Pertussis, URTI, H. pylori, and mycobacterial infections

Monitor QTc in patients with increased risk

  • GI upset, diarrhea
  • Rash
  • Prolongation of QTc interval
  • Substrate of CYP3A4.
  • Multiple CYP450 interactions possible - consult a pharmacist for more detail. May increase digoxin, carbamazepine level. Use caution with QTc prolonging medications.

Antimicrobial class: Macrolide

Average serum half life:

Adult:

  • Clarithromycin: 3-7 hours
  • 14-OH-clarithromycin (active metabolite): 5-9 hours

Route of Elimination: Urine (20-40% as unchanged drug, additional 10%-15% as active metabolite); feces (29% to 40% mostly as metabolites)