Antimicrobials
Cefotaxime

Cefotaxime

High
N/A

Spectrum of Activity

General Information

Empiric therapy for bacterial meningitis, pneumonia, intra-abdominal infection including SBP, musculoskeletal i.e. septic arthritis, and urinary tract infection.

Rash, localized phlebitis at injection site, allergy.

Positive Coombs test, neutropenia, diarrhea.

Preferred cephalosporin in neonates.

Outside of the neonatal period, cefotaxime may be automatically substituted by AHS pharmacy to ceftriaxone unless "no substitution" is specified.

Antimicrobial class: 3rd Generation Cephalosporin

Average serum half life:

  • neonates: 3.4-4.6 hours.

  • children: 1.5 hours

Route of Elimination: urine: ~60% as unchanged drug and metabolites in urine