Antimicrobials
Ampicillin

Ampicillin

Low
N/A

General Information

Pathogen directed therapy for CNS, intravascular, intraabdominal, urinary and other infections esp enterococcus and listeria. As part of empiric therapy for early onset sepsis in neonates.

Renal & liver function.

CBC with differential.

  • Allergy and rash

  • EBV related rash (not allergy)

  • Rare: cytopenias, +ve Coombs

Antimicrobial class: Aminopenicillin

Average serum half life:

  • Neonates

    • PNA 2-7days: 4 hours
    • PNA 8-14 days: 2.8 hours
    • PNA 15-30 days: 1.7 hour
  • Pediatrics: 1-1.8 hours

  • Anuric patients: 8-20 hours

Route of Elimination:

  • 90% excreted unchanged in urine within 24 hours Excreted in bile