General Spectrum of Activity
Fungicidal therapy of yeast/fungus/mold infection, especially of the urinary tract as lipid formulations are otherwise preferred to minimize toxicity
Induction therapy for dimorphic fungii (cocci, blasto, histo)
Renal function, fluid status, serum electrolytes (K, Mg).
Liver enzymes, CBC with differential.
Enhance nephrotoxic effect with concomitant use of other nephrotoxins - use should be minimized during amphotericin therapy.
Premedication with acetaminophen, diphenhydramine, or hydrocortisone for infusion related symptoms.
Antimicrobial class: Antifungal - polyene
Average serum half life:
Route of Elimination: Urine (2% to 5% unchanged); ~40% eliminated over 7-day period and may be detected in urine for up to 8 weeks after discontinued use