Antimicrobials
Cotrimoxazole (Trimethoprim-Sulfamethoxazole)

Cotrimoxazole (Trimethoprim-Sulfamethoxazole)

Low
Excellent
See below

Spectrum of Activity

Dosing

General Information

  • N10/480mg tab
  • N20/960mg tab
  • N150-N350/susp
  • Urinary tract infections
  • Susceptible MRSA infections
  • Stenotrophomonas infections
  • Pneumocystis jirovecii pneumonia (Treatment or prophylaxis)

Follow creatinine and electrolytes in patients at increased risk renal failure, hyperkalemia.

  • Megaloblastic anaemia
  • Disturbance
  • Rash
  • Erythema multiforme major/minor
  • ACEi - Increased serum potassium level
  • Increases amantadine levels
  • Decreases cyclosporine
  • Methotrexate - Marrow suppression
  • Increases phenytoin
  • Increases rifampin
  • Increases INR with warfarin

Antimicrobial class: Sulfonamide - Antifolate

Pregnancy category: C

Average serum half life: 10 hours

Urine penetration: Therapeutic

Lung penetration: Therapeutic

CSF penetration: Therapeutic

Biliary penetration: Moderate